mosaiques diagnostics GmbH

mosaiques diagnostics GmbH Logo

mosaiques diagnostics GmbH
Mellendorfer Str. 7-9
30625 Hannover

Project Leader

Dr. Petra Zürbig

Dr. Petra Zürbig
Phone: +49 511 5547 4415
Fax: +49 511 6647 4431

Project Staff

Prof. Harald Mischak
Scientist and Project Manager
Phone: + 49 511 5547 4413

Dr. Eric Schiffer
Scientist and Project Manager
Phone: +49 511 5547 4417

Thomas Soeffing
IT specialist and database administrator
Phone: +49 511 5547 4418

Marco Schiemann
Phone: +49 511 5547 4439


Dr. Petra Zürbig, Prof. Harald Mischak, Dr. Eric Schiffer
From left to right: Dr. Petra Zürbig, Prof. Harald Mischak, Dr. Eric Schiffer

Company Presentation

Fields of excellence

Mosaiques Diagnostics GmbH (MOS) is the leading specialist in clinical proteome and capillary electrophoresis coupled to mass spectrometry (CE-MS) analysis, currently the most advanced technology to identify disease-specific polypeptide biomarkers in body fluids (figure 1). MOS has published more than 100 manuscripts in leading journals and has also led the consortium that defined standards for clinical proteome analysis. The company has successfully participated in several FP6 and FP7 projects, e.g. INCA, UroSysteomics, InGeniuosHpyercare, SysKID, EU-MASCARA.

MOS main research activities are identification of urinary biomarkers for human diseases; sequencing of peptide biomarkers, development of software to analyze multidimensional data; and establishment of proteome maps of human body fluids. Among the major clinical areas of interest is the application of urinary proteomics in the early detection and prognosis of renal diseases, aiming at early and personalized intervention based on the molecular data and patho-physiology.

Capillary electrophoresis - mass spectrometer (CE-MS)
Figure 1: Peptides of a urine sample are separated using capillary electrophoresis and detected in a mass spectrometer yielding a quality controlled polypeptide profile of the specimen. The individual profile will be processed, calibrated, normalized and compared to a disease specific biomarker panel using support vector machine (SVM) algorithms.

Principal Investigator

Petra Zürbig received her PhD in Chemistry from the RWTH Aachen in 1997. Between 1998 and 2001 she worked as a postdoctoral fellow on the isolation and characterization of orphan receptor ligands from human hemofiltrate and porcine brain at the Lower Saxony Institute for Peptide Research (IPF), Germany. Here she worked at the department of peptide analysis and achieved deep insight into sequence analysis of peptides via mass spectrometric approaches. She completed her mass spectrometric knowledge as scientist at BioVisioN AG, Germany from 2001-2002. In 2003 she took up the position as head of the proteomics laboratory at the Fraunhofer Institute of Toxicology and Experimental Medicine (ITEM), Germany. Since 2005 she holds the position as group leader of Mosaiques diagnostics GmbH. In addition, she is the project manager of all kidney disease and aging projects. In addition, she is one of the founding members of the DGPF (German Society of Proteome Research). She is one of 15 authors, who published most papers on clinical proteomics in the last 5 years. With this experience in protein/peptide analyses, she is an expert in the fields of proteomic and peptidomic approaches.

Relevant qualifications, experience and knowledge

MOS is currently the only institution worldwide that can reproducibly analyze hundreds of samples with mass spectrometry in a short time, based on a unique and proprietary database of proteins and peptides in human body fluids. MOS also has ample experience in clinical studies and in the evaluation of multidimensional datasets. The technological platform has been evaluated by both, EMA, and FDA, and was found acceptable by both regulatory agencies. MOS has developed proprietary hardware for analysis and software solutions for data evaluation. Consequently, MD has a unique and proprietary database of proteins and peptides in human body fluids of currently >20,000 samples (containing >100,000 different peptides and proteins) and their relevance in different diseases.

The team at mosaiques diagnostics GmbH
The team at mosaiques diagnostics GmbH.